By 2020 most developed countries will have established comprehensive electronic Health Record systems to track lifetime patient medical and general population health histories, including personal DNA genome sequences and SNP microarray test results. An individual’s medical records will then provide personalised drug and vaccine protocols based on genetic response variants. Whole-of-life e-health records will be accessible across the developed and much of developing world, eventually allowing the creation of online global networks of population health records from pre-birth to death.
Global e-Health archiving will also accelerate the provision of expert biomedical advice and services to populations across the planet, utilising the communication modalities of the Web and smart mobile phone technologies. These will also function as personalised helpers, performing real-time monitoring and transmission of vital patient status data including images, via ubiquitous sensor networks. These will forward continuous data to government and private healthcare hubs for expert online assessment and intervention.
In addition, health and lifestyle support will be managed increasingly in conjunction with global professional care and patient social networks. Such networks operating via the open standards of web-based technologies will promote collaboration between patients, caregivers and health providers, offering interactive exchange of case information- symptoms, diagnosis and treatment options; improving lifestyle outcomes and ensuring individuals feel less isolated.
By 2025 A Universal Health Grid will be in operation connecting e-health client records seamlessly across all nations;. providing ubiquitous communication support for the acquisition and delivery of life enhancement knowledge on a global basis. In addition, scanned images will be linked in vast virtual databases, to provide remote expert support to local medical teams and practitioners. This will facilitate advanced surgical techniques, applied remotely using robotic, virtual and augmented reality technologies.
By 2030 tens of thousands of human genomes from diverse populations will have been sequenced and made available online for research into the genetic basis of common diseases. Analysis will have moved from understanding the role of single gene mutations to the highly complex networks of multiple genetic interactions. Polygenic natural selection has allowed new traits to rapidly sweep through populations in the past, allowing humans to adapt to extreme climates and new food sources
The genetic basis of the major diseases and injuries afflicting humans will have been traced and effective therapies addressed covering- Neurodegenerative - such as Parkinson’s and Alzheimers; Pathogenic and parasitic based- - such as malaria, dengue fever, cholera and lyme; Cancers and auto-immune diseases; Organ failure- such as heart, pancreas, lung, liver and kidney; Injuries to nervous system, joints and bone- such as spinal cord trauma and arthritis. Improvements in therapies will continue at an accelerating rate.
In addition, the power of the web will be supported by a new way of unlocking a deeper understanding of nature and its evolution in the form of Systems Biology- already marking a paradigm shift from traditional reductionism to a more holistic level of understanding of biological phenomena. This approach interprets organisms in terms of information processing networks at the system rather than component genetic, proteins and environmental level. Systems biology also marks the beginning of a more quantitative science, highlighting the causality and dynamics of biological interactions by applying mathematical models and the capability of simulating interactions at all levels- cells, organs and the total organism.
Stem Cell therapies, including both adult and embryonic stem cell differentiation, will be commonly applied to the repair of human tissue and organs including—skin, cartilage, blood vessels, bone, eyes, spine, pancreas, liver and heart muscle. The future treatment of diseases such as heart failure and breast cancer will be revolutionised by such technologies, with the option of growing new organs and tissue inside the human body using the patient’s own stem cells and biodegradable scaffolds to avoid immune rejection.
Stem cell technology will complemented by Molecular Engineering techniques such as gene therapy, involving the correction of genetic mutations by inserting reengineered genes into cells. Molecular engineers are already beginning to create custom-built proteins with enhanced functions, including the capacity to correct disease genes causing hemophilia, muscular dystrophy and sickle cell anemia.
Understanding the role of RNA in cells will also be vital in understanding gene silencing and targeting cancer and other diseases.
By 2035 Cyber-Human symbiosis will also be routinely applied, allowing the direct linkage between computer-electronic control and virtual reality technologies and human biological systems. This science is already includes the use of -
Sensory augmentation implants such as early retinal and corneal implants;
prosthetics such as a neurally-controlled limbs; brain interfaces, overcoming paralysis using brain signals; artificial hippocampus- assisting patients with memory deficits;
brain image extraction and reconstruction and interactive humanoid robots to provide human companionship and physical support.
By 2040 Neuro-Engineering technology will be commonly applied enabling enhancement of human intelligence, memory and creativity. Significant advances are already being made towards simulating the brain’s capacity for sensation, perception, action, interaction and cognition, using advanced 3D fMRI and Optogenetics technologies; allowing better analysis of neural circuits to reveal new neural regulation and drug treatment targets.
Cognitive enhancement compounds will also be widely used. These will be applied to Alzheimer’s and other forms of dementia as well as generally enhancing human decision-making, alertness and memory capability. The impact of cyberspace on the evolution of the brain is also likely to be very significant over the coming decades. Children are constantly being neurally rewired as the interactive Web becomes an essential part of their lives in the form of virtual realities, multimedia and social networking.
Brain simulation is also a nascent field offering huge future potential. A brain with a billion neurons and ten trillion synapses- equivalent to a cat’s cortex or 4.5% of a human brain has been simulated by IBM; while a team of European scientists have taken the first steps towards creating a silicon chip designed to function like a the cortex of a human brain. With research and development converging on all fronts in this field- both at the hardware and software level, it will be only a matter of time before a brain with human-level complexity is scaled up for experimental use.
Molecular biology has largely been applied as a reductive science but now synthetic biologists are beginning to build machines from interchangeable DNA parts that work inside living cells, deriving energy, processing information and eventually reproducing. Flexible reliable fabrication technology, together with standardised methods and design libraries have enabled a new generation of biological engineers to already create new organisms from biological components from the ground up..
By 2045 the nanobiotechnology revolution of new and enhanced life forms will be common. For the first time in human history an artificial life form with synthetic DNA has been created by Craig Venter This will open a portal for the explosion of human potential beyond the confines of biological evolution alone. In addition, Medibots are being designed. These are tiny robots only a few millimetres in size that can work internally and are designed to enter the body through the mouth, ears, eyes or lungs and swim through the bloodstream.
These will be widely used to conduct robotic surgery, install medical devices, including a camera in a capsule small enough to be swallowed, deliver drugs and take tissue samples. Nanoscale machines and motors will be inserted inside cells which can then self-assemble and seamlessly integrate with other cell functions. Smart implants and tiny biological fuel cells are also on the drawing board, capable of producing electricity from glucose and oxygen in the bloodstream.
By 2050 the super-intelligent Web 4.0 will have combined human and artificial intelligence. It will be ubiquitous, powered by a smart computational sensory, grid/mesh, enveloping and connecting human life and encompassing all facets of social and scientific activity- always on and available.
This capability will be essential for supporting the immensely complex decision-making and problem solving requirements essential for civilisation's future progress, including applying algorithms to manage medical research, diagnosis and treatment. The Web will then have emerged as the senior partner in complex medical diagnosis and specialist intervention, as well as genetic discoveries; driving health progress into the future.
Within 40 years the rate of medical/health advances will have accelerated knowledge discovery to the point where it will begin to eliminate most human diseases, doubling human lifespan to 150 years. Combined with accepted human cloning and breakthroughs in organ replacement and cognitive enhancement, the stage will be set for the emergence of a new generation of Transhumans.
Global e-Health archiving will also accelerate the provision of expert biomedical advice and services to populations across the planet, utilising the communication modalities of the Web and smart mobile phone technologies. These will also function as personalised helpers, performing real-time monitoring and transmission of vital patient status data including images, via ubiquitous sensor networks. These will forward continuous data to government and private healthcare hubs for expert online assessment and intervention.
In addition, health and lifestyle support will be managed increasingly in conjunction with global professional care and patient social networks. Such networks operating via the open standards of web-based technologies will promote collaboration between patients, caregivers and health providers, offering interactive exchange of case information- symptoms, diagnosis and treatment options; improving lifestyle outcomes and ensuring individuals feel less isolated.
By 2025 A Universal Health Grid will be in operation connecting e-health client records seamlessly across all nations;. providing ubiquitous communication support for the acquisition and delivery of life enhancement knowledge on a global basis. In addition, scanned images will be linked in vast virtual databases, to provide remote expert support to local medical teams and practitioners. This will facilitate advanced surgical techniques, applied remotely using robotic, virtual and augmented reality technologies.
By 2030 tens of thousands of human genomes from diverse populations will have been sequenced and made available online for research into the genetic basis of common diseases. Analysis will have moved from understanding the role of single gene mutations to the highly complex networks of multiple genetic interactions. Polygenic natural selection has allowed new traits to rapidly sweep through populations in the past, allowing humans to adapt to extreme climates and new food sources
The genetic basis of the major diseases and injuries afflicting humans will have been traced and effective therapies addressed covering- Neurodegenerative - such as Parkinson’s and Alzheimers; Pathogenic and parasitic based- - such as malaria, dengue fever, cholera and lyme; Cancers and auto-immune diseases; Organ failure- such as heart, pancreas, lung, liver and kidney; Injuries to nervous system, joints and bone- such as spinal cord trauma and arthritis. Improvements in therapies will continue at an accelerating rate.
In addition, the power of the web will be supported by a new way of unlocking a deeper understanding of nature and its evolution in the form of Systems Biology- already marking a paradigm shift from traditional reductionism to a more holistic level of understanding of biological phenomena. This approach interprets organisms in terms of information processing networks at the system rather than component genetic, proteins and environmental level. Systems biology also marks the beginning of a more quantitative science, highlighting the causality and dynamics of biological interactions by applying mathematical models and the capability of simulating interactions at all levels- cells, organs and the total organism.
Stem Cell therapies, including both adult and embryonic stem cell differentiation, will be commonly applied to the repair of human tissue and organs including—skin, cartilage, blood vessels, bone, eyes, spine, pancreas, liver and heart muscle. The future treatment of diseases such as heart failure and breast cancer will be revolutionised by such technologies, with the option of growing new organs and tissue inside the human body using the patient’s own stem cells and biodegradable scaffolds to avoid immune rejection.
Stem cell technology will complemented by Molecular Engineering techniques such as gene therapy, involving the correction of genetic mutations by inserting reengineered genes into cells. Molecular engineers are already beginning to create custom-built proteins with enhanced functions, including the capacity to correct disease genes causing hemophilia, muscular dystrophy and sickle cell anemia.
Understanding the role of RNA in cells will also be vital in understanding gene silencing and targeting cancer and other diseases.
By 2035 Cyber-Human symbiosis will also be routinely applied, allowing the direct linkage between computer-electronic control and virtual reality technologies and human biological systems. This science is already includes the use of -
Sensory augmentation implants such as early retinal and corneal implants;
prosthetics such as a neurally-controlled limbs; brain interfaces, overcoming paralysis using brain signals; artificial hippocampus- assisting patients with memory deficits;
brain image extraction and reconstruction and interactive humanoid robots to provide human companionship and physical support.
By 2040 Neuro-Engineering technology will be commonly applied enabling enhancement of human intelligence, memory and creativity. Significant advances are already being made towards simulating the brain’s capacity for sensation, perception, action, interaction and cognition, using advanced 3D fMRI and Optogenetics technologies; allowing better analysis of neural circuits to reveal new neural regulation and drug treatment targets.
Cognitive enhancement compounds will also be widely used. These will be applied to Alzheimer’s and other forms of dementia as well as generally enhancing human decision-making, alertness and memory capability. The impact of cyberspace on the evolution of the brain is also likely to be very significant over the coming decades. Children are constantly being neurally rewired as the interactive Web becomes an essential part of their lives in the form of virtual realities, multimedia and social networking.
Brain simulation is also a nascent field offering huge future potential. A brain with a billion neurons and ten trillion synapses- equivalent to a cat’s cortex or 4.5% of a human brain has been simulated by IBM; while a team of European scientists have taken the first steps towards creating a silicon chip designed to function like a the cortex of a human brain. With research and development converging on all fronts in this field- both at the hardware and software level, it will be only a matter of time before a brain with human-level complexity is scaled up for experimental use.
Molecular biology has largely been applied as a reductive science but now synthetic biologists are beginning to build machines from interchangeable DNA parts that work inside living cells, deriving energy, processing information and eventually reproducing. Flexible reliable fabrication technology, together with standardised methods and design libraries have enabled a new generation of biological engineers to already create new organisms from biological components from the ground up..
By 2045 the nanobiotechnology revolution of new and enhanced life forms will be common. For the first time in human history an artificial life form with synthetic DNA has been created by Craig Venter This will open a portal for the explosion of human potential beyond the confines of biological evolution alone. In addition, Medibots are being designed. These are tiny robots only a few millimetres in size that can work internally and are designed to enter the body through the mouth, ears, eyes or lungs and swim through the bloodstream.
These will be widely used to conduct robotic surgery, install medical devices, including a camera in a capsule small enough to be swallowed, deliver drugs and take tissue samples. Nanoscale machines and motors will be inserted inside cells which can then self-assemble and seamlessly integrate with other cell functions. Smart implants and tiny biological fuel cells are also on the drawing board, capable of producing electricity from glucose and oxygen in the bloodstream.
By 2050 the super-intelligent Web 4.0 will have combined human and artificial intelligence. It will be ubiquitous, powered by a smart computational sensory, grid/mesh, enveloping and connecting human life and encompassing all facets of social and scientific activity- always on and available.
This capability will be essential for supporting the immensely complex decision-making and problem solving requirements essential for civilisation's future progress, including applying algorithms to manage medical research, diagnosis and treatment. The Web will then have emerged as the senior partner in complex medical diagnosis and specialist intervention, as well as genetic discoveries; driving health progress into the future.
Within 40 years the rate of medical/health advances will have accelerated knowledge discovery to the point where it will begin to eliminate most human diseases, doubling human lifespan to 150 years. Combined with accepted human cloning and breakthroughs in organ replacement and cognitive enhancement, the stage will be set for the emergence of a new generation of Transhumans.
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